CASE REPORT   

Chirurgia 2018 February;31(1):39-43

DOI: 10.23736/S0394-9508.17.04711-8

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Multiple systemic extraneural metastasis of glioblastoma

Kyoung S. SUNG ¹, Tae H. ROH ², Se H. KIM ^{3, 4}, Hye J. CHOI ^{4, 5}, Jin S. YOON ⁶, Chang-Ok SUH ^{4, 7}, Jong H. CHANG ^{4, 8} ✉

¹ Department of Neurosurgery, Dong-A University Hospital, Dong-A University College of Medicine, Busan, South Korea; ² Department of Neurosurgery, Ajou University Hospital, Ajou University College of Medicine, Suwon, South Korea; ³ Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea; ⁴ Brain Tumor Center, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea; ⁵ Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea; ⁶ Department of Ophthalmology, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea; ⁷ Department of Radiation Oncology, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea; ⁸ Department of Neurosurgery, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea

We present a rare case of extraneural metastatic glioblastoma (GBM) with review of literatures. The patient remained healthy for approximately 1 year after operation, without signs of intracranial recurrence. Thereafter, he presented severe right sided orbital and facial pain with severe right-conjunctival injection and chemosis. Brain magnetic resonance imaging revealed multiple tumors in the bilateral extraocular muscles (EOM) and the right infratemporal fossa. Laboratory examination revealed thrombocytopenia. Multiple metastatic tumors in the neck and the multiple levels of vertebrae were detected using whole-body positron emission tomography. We performed biopsies of the bone marrow and EOM. Pathological results confirmed metastatic GBMs.

KEY WORDS: Glioblastoma - Neoplasm metastasis - Oculomotor muscles