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Chirurgia 2017 December;30(6):191-5

DOI: 10.23736/S0394-9508.17.04660-5


language: English

Protective effects of curcumin on postoperative adhesions in rat models

Talha SARIGOZ 1 , Yusuf SEVIM 2, Hasan DIRIK 3, Fatih MUTLU 4, Omer TOPUZ 1, Tamer ERTAN 1, Inanc S. SARICI 5

1 Department of General Surgery, Kayseri Training and Research Hospital, Kayseri, Turkey; 2 Department of General Surgery, Numune Training and Research Hospital, Ankara, Turkey; 3 Department of Critical Care Medicine, Erciyes University Faculty of Medicine, Kayseri, Turkey; 4 Department of General Surgery, Adnan Menderes University Faculty of Medicine, Aydin, Turkey; 5 Department of General Surgery, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey


BACKGROUND: Curcumin is the main component of curry spices known as turmeric. Turmeric comes from the Zingiberaceae plant family and it is a traditional Chinese herb used for inflammatory conditions. It has gained popularity over the last decades and became the subject of scientific researches because of its anti-inflammatory and anti-oxidant activity.
METHODS: The present study is an animal experimentation and designed as a pilot study. Twenty-four 5- to 6-week-old female Wistar Albino rats weighing 150-250 g were used. They were randomized into 3 groups as sham, control and study groups each consisting of 8 rats. One percent dimethyl sulfoxide was administered intraperitoneally in control group, and in study group, curcumin powder was dissolved in 1% dimethyl sulfoxide and administered intraperitoneally at a dose of 200 mg/kg. Effects of curcumin on adhesion formation, and oxidative stress were evaluated.
RESULTS: Macroscopic adhesion scores in sham and study groups were significant lower compared to control group (P<0.05). Vascular proliferation, fibroblastic activity, and inflammation scores were identified lower in sham group compared to control group (P<0.05). The oxidative status of the groups was investigated and lower TAS values were detected in sham group compared to control group (P<0.05). Additionally, TOS values were significantly low in the study group compared to control group (P<0.05).
CONCLUSIONS: Curcumin seems reducing intra-abdominal adhesion formation significantly with dose-dependent anti-inflammatory, and antioxidant effects.

KEY WORDS: Curcumin - Wound healing - Curcuma - Animal models

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