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Chirurgia 2013 April;26(2):101-10


language: English

Intraspinal ependymomas: case series study of myxopapillary and intramedullary ependymomas

Figueiredo N. 1, 2, Brooks N. 1, Hanna A. 1, Baskaya M. K. 1, Trost G. R. 1, Resnick D. K. 1

1 UW-Madison - Department of Neurological Surgery University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; 2 UFMT – Medical School, Federal University of Mato Grosso, Cuiaba, MT, Brazil


Aim: The aim of the study was to study the data regarding intraspinal ependymoma (ISE) of patients operated at the University of Wisconsin Hospital.
Methods: Information on consecutive individuals with ISE operated between 1998 and 2012 was retrospectively collected and analyzed.
Results: Data regarding 38 patients, 19 with myxopapillary ependymoma (MPE), gross-total resection (GTR) was achieved in 14, seven en bloc GTR, all remained disease-free, seven piecemeal GTR, and two cases had tumor recurrence. Subtotal resection (STR) was accomplished in two, they were submitted to XRT, and they were living with stable disease. Partial removal was performed in two, they were re-operated and submitted to XRT, and were living with the neoplasm. Biopsy was performed in one patient. Thirteen remained disease-free and six had tumor recurrence, progression and/or stable disease. Nineteen patients were operated for intramedullary ependymoma (IME), GTR was achieved in 11, being four en bloc GTR, six piecemeal, not specified in one case, and all remained disease-free. Subtotal resection was accomplished in six, three were living with stable disease; two with progression of the neoplasm, and one died after this tumor progression. Partial removal was performed in two, they were submitted to XRT, one deceased, and another was living with stable tumor. Eleven were disease-free, and eight had tumor recurrence, progression and/or stable disease.
Conclusion: This study suggested that the lowest recurrence rate occurred at the group who underwent GTR, with an added advantage of for an en bloc gross-total resection of MPE. Residual disease that is not resectable may be controlled with radiation therapy.

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