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Chirurgia 2006 February;19(1):87-91

Copyright © 2006 EDIZIONI MINERVA MEDICA

language: English

Conservative management of an unusual Paget’s disease of the nipple. A case report and review of the literature

Franceschini G. 1, Masetti R. 1, Persiani R. 1, D’Ugo D. 2, Di Leone A. 1, Mulè A. 3, Costantini M. 4, Picciocchi A. 1

1 Department of Surgery “A. Gemelli” Medical School, Rome, Italy 2 Surgical Oncology Unit Catholic University at Campobasso, Italy 3 Department of Pathology “A. Gemelli” Medical School, Rome, Italy 4 Department of Radiology “A. Gemelli” Medical School, Rome, Italy


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Paget’s disease of the breast accounts for only 0,5-4,3 percent of all patients with breast cancer; bilateral Paget’s disease is extremely unfrequent. We report an unusual case of synchronous bilateral Paget’s disease of the breast in a 73-year-old woman, associated with an underlying ductal carcinoma in situ of the right breast and with an invasive micropapillary carcinoma in the controlateral breast. Breast-conserving surgery and radiotherapy were performed. The presence of bilateral Paget’s disease with the coexistence of two underlyng synchronous and bilateral breast cancers apparently support the secondary origin of Paget’s disease (epidermotropic theory), indicating the need to search for an underlying neoplasm in the parenchyma in each case of Paget’s disease.

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