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Medicina e Chirurgia della Caviglia e del Piede 2020 April;44(1):3-13

DOI: 10.23736/S2284-2993.20.01811-7

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: Italian

Use of second-generation blood products in regenerative therapy of complex extremity wounds

Alessandro CRISCI 1, 2 , Tomoyuki KAWASE 3, Raffaele D’ADAMO 2, Michela CRISCI 2

1 Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Fisciano, Salerno, Italy; 2 Unit of Skin Surgery, Skin Transplants and Difficult Wounds, “Villa Fiorita” Nursing Home, Aversa, Caserta, Italy; 3 Division of Oral Bioengineering, Institute of Medicine and Dentistry, Niigata University, Niigata, Japan



Regeneration is the ultimate aim in the field of multidisciplinary tissue engineering, as well as the amelioration or substitution, in a predictable manner, of damaged or missing tissues, as a result of a variety of reasons, including trauma, diseases and aging. To guarantee an ample availability of different tissue engineering techniques, in clinical fields, these need to be changed and adapted in order to render them accessible and relatively easy to apply in everyday clinical routines. Choukroun platelet fibrin (PRF) and its derivatives have been implemented in a vast array of medical fields, as a supra-natural concentrate of autologous growth factors, able to simulate tissue regeneration. Platelet have been found inside blood clots, in its entirety, in all its different groups, even if inside the A-PRF group, the platelet counts is higher in the distal portion, distal from the Buffy coat (BC), compared to L-PRF. T and B lymphocytes, stem cells, and monocytes have been found close to the BC. Lowering the number of spins and increasing the duration of centrifugation in the A-PRF group lead to a higher neutrophil count in the distal portion of the clots. In conclusion, the results of this systematic study have highlighted the positive effects of PRF and its derivatives (A-PRF, i-PRF) in wounds healing, after regenerative therapy of complicated cutaneous foot lesions.


KEY WORDS: Stem cells; Platelet-rich fibrin; Wounds

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