Home > Journals > Medicina e Chirurgia della Caviglia e del Piede > Past Issues > Medicina e Chirurgia della Caviglia e del Piede 2017 August;41(2) > Medicina e Chirurgia della Caviglia e del Piede 2017 August;41(2):29-32

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Medicina e Chirurgia della Caviglia e del Piede 2017 August;41(2):29-32

DOI: 10.23736/S2284-2993.17.01758-6

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: Italian

A rare case of desmoplastic fibroblastoma (collagenous fibroma) of the foot

Stefano BIGGI 1 , Valentina GALLINA 1, Francesca SAROCCHI 2, Giulio FRATERNALI ORCIONI 2, Lamberto FELLI 1

1 Orthopedics and Traumatology Unit, IRCCS San Martino IST, Genoa, Italy; 2 Anatomic Pathology and Cytodiagnostics Unit, IRCCS San Martino IST, Genoa, Italy


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Desmoplastic fibroblastoma (DF) is a rare soft tissue tumor. It may be mistaken for other benign or even malignant tumors of soft tissue because of the small number of issues in literature. We report on an unusual presentation in the first intermetatarsal space mismatching a cyst. The mass was a circumscribed lesion, measuring 2.5×1.5×1.2 cm, and it was nodular, non-tender, pearly-white-colored, with alternating translucent from gray-to-white areas in section. Histological evaluation showed an expansile lesion with peripheral pseudocapsule consisting of a mesenchymal hypocellular proliferation intermixed with abundant collagenous stroma. Immunohistochemical staining demonstrated a strong positive reaction for vimentin, and a weak and focal positivity for alpha-smooth muscle actin. Reaction for MUC-4, desmin, CD34, cytokeratin AE1/AE3, EMA, S100, and β-catenin were negative. After resection, at 4 years’ follow-up there was no recurrence. DF may be a benign soft-tissue tumor, however its diagnosis can be difficult due to heterogeneous symptoms and anatomical sites.


KEY WORDS: Foot - Desmoplastic fibroma - Soft tissue neoplasms

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