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Rivista Italiana di Chirurgia Maxillo-Facciale 2004 April;15(1):9-13


language: English

Primary extranodal non-Hodgkin’s lymphomas of the cervical facial area: critical revision of the casuistry

Lancellotti L. 1, Cocchi R. 2, Maestri A. 3, Foschini M. P. 4, Stea S. 1

1 Unit of Maxillo-Facial Surgery, Villa Maria Cecilia Hospital, Cotignola; Ravenna 2 Unit of Maxillo-Facial Surgery, Bellaria Hospital, Bologna 3 Department of Oncologic Science Unit of Oncology, Bellaria Hospital, Bologna 4 Department of Oncologic Science Unit of Pathology University of Bologna, Bellaria Hospital, Bologna


Extranodal lymphomas represents almost 7-8% of all B cell lymphomas. Possible places are the oral cavity, central nervous system, testicle, heart, lungs, thyroid gland, pancreas, breast, eye and orbit cavities, skin, paranasal sinus, stomach, small intestine and colon, salivary glands. The extranodal LNH arising in the cervical-facial area are a rare pathology and represent about 23% of the LNH of the head and neck. The clinical picture of the extranodal LNH is very changeable depending on the histological type and on the developing location of the disease. We may suppose that extranodal lymphomas arise from immune-competent cells not organized in lymphoid structures. A continuous phlogistical stimulus may be responsible of the selection in developing an extranodal lymphoma. The peculiar rising site and the frequent involvement of the near organs (for example the eye) make the diagnostic and therapeutic approach of this lymphoma much more problematic. The clinical course and prognosis of extranodal LNH is very heterogeneous depending first on the histological type and then on the rising site of the primitive lesion. The therapeutical treatment with RT alone or with both chemiotherapy and RT allows to a high percentage of complete eradication of the disease with frequent possible damages post treatment due to the presence of noble structures in the head and neck site.

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