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REVIEW  NEWEST EVIDENCE IN BIOMATERIALS FOR AORTIC AND VALVE GRAFTS 

The Journal of Cardiovascular Surgery 2020 October;61(5):577-85

DOI: 10.23736/S0021-9509.20.11615-X

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Vascular grafts and valves that animate, made from decellularized biologically-engineered tissue tubes

Zeeshan H. SYEDAIN 1, Robroy MACIVER 2, Robert T. TRANQUILLO 1, 3

1 Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA; 2 Children’s Hospitals and Clinics of Minnesota, Minneapolis, MN, USA; 3 Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, USA



Biologically-engineered matrix - a tissue that is grown in vitro from donor cells, decellularized, and stored prior to use as off-the-shelf allografts - offers a promising alternative to current cardiovascular biomaterials. This perspective reviews preclinical studies and clinical trials of vascular grafts and valves comprising biologically-engineered matrix, with a focus on those based on donor dermal fibroblast remodeling of fibrin gel with the capacity to heal and grow following recellularization, via animation of the matrix. It concludes with a discussion of related key clinical considerations.


KEY WORDS: Bioengineering; Tissue engineering; Regenerative medicine; Vascular grafting; Heart valve; Venous valves

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