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REVIEW  EVOLVING TECHNOLOGIES FOR INFRA-INGUINAL ARTERIAL DISEASE 

The Journal of Cardiovascular Surgery 2018 August;59(4):526-8

DOI: 10.23736/S0021-9509.18.10578-7

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Direct drug delivery in the treatment of steno-occlusive disease of the infra-inguinal arteries

Vinayak SUBRAMANIAN 1, Ivy SMITH 2 , George ADAMS 1, 2

1 UNC School of Medicine, Chapel Hill, NC, USA; 2 UNC Health Care System, Chapel Hill, NC, USA


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Peripheral Artery disease (PAD) is a cause of significant morbidity and mortality, affecting over 200 million people world-wide. Many exciting technologies have emerged to address the unique challenges endovascular specialists face when treating lesions in this vascular bed. One of the
enduring challenges has been restenosis after initial intervention. Here we highlight a new technology, Direct drug delivery, to address this challenge and exciting prospects. Direct drug delivery constitutes delivering drug directly to the vessel wall through a needle with a micro-infusion catheter. This device has the potential to expand the types of therapies that can be delivered in a targeted fashion and allow endovascular specialists to individualize treatment for patients.


KEY WORDS: Peripheral arterial disease - Ischemia - Arterial occlusive diseases - Drug delivery systems - Balloon angioplasty - Dexamethasone - Biological therapy

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