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REVIEW  CARDIAC SECTION 

The Journal of Cardiovascular Surgery 2017 October;58(5):770-8

DOI: 10.23736/S0021-9509.16.09352-6

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

There is no association between TNF-α gene polymorphisms and the risk of coronary artery heart disease: a meta-analysis

Fengtian HUANGFU 1, Xin ZHAO 2, Xin WANG 1, Longqian TANG 3, Jie JIANG 4

1 Department of Cardiology, Jinan 4th Hospital, Jinan, China; 2 Department of Healthcare, Jinan 4th Hospital, Jinan, China; 3 Shandong University School of Medicine, Jinan, China; 4 Department of Emergency, Jinan 4th Hospital, Jinan, China


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INTRODUCTION: Coronary artery heart disease (CAD) is a group of complex diseases, including coronary atherosclerosis, myocardial infarction and sudden cardiac death. CAD is also widely accepted as a chronic inflammatory disease. Studies show that pro-inflammatory tumor necrosis factor-alpha (TNF-α) is involved in the CAD pathological pathway and is a reliable predictor of cardiovascular disease. However, the association between TNF-α polymorphisms and CAD risk is still unclear. In this meta-analysis, we investigated the relationship between TNF-α polymorphisms and CAD risk.
EVIDENCE ACQUISITION: From EMBASE, Web of science, EBSCO, PubMed and Chinese National Knowledge Infrastructure (CNKI) databases 7525 articles were selected in our study. A meta-analysis on the associations between the T-1031C, C-857T and C-863A polymorphisms and CAD risk was carried out by comparing five genetic models.
EVIDENCE SYNTHESIS: In this systematic review 14 studies from six English articles and 1 Chinese article were analyzed. The pooled population included 16,774 subjects (8351 cases and 8423 controls). Our results showed that three polymorphisms (T-1031C, C-857T and C-863A) have no association with CAD risk.
CONCLUSIONS: Our results indicated that T-1031C, C-857T and C-863A polymorphisms are not associated with CAD risk.


KEY WORDS: Tumor necrosis factor-alpha - Polymorphism, genetic - Coronary artery disease - Meta-analysis

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