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ORIGINAL ARTICLE  CARDIAC SECTION 

The Journal of Cardiovascular Surgery 2017 August;58(4):591-7

DOI: 10.23736/S0021-9509.16.09390-3

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Comparison of periprocedural and mid-term stroke rates and outcomes between surgical aortic valve replacement and transcatheter aortic valve replacement patients

Seyed Hossein, AALAEI-ANDABILI 1, R. David ANDERSON 2, John W. PETERSEN 2, Thomas M. BEAVER 1, Anthony A. BAVRY 2, 3, Charles T. KLODELL 1

1 Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Florida, Gainesville, FL, USA; 2 Division of Cardiology, Department of Medicine, University of Florida, Gainesville, FL, USA; 3 North Florida/South Georgia Veterans Health System, Gainesville, FL, USA


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BACKGROUND: We compared stroke occurrence and outcomes between Transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR), both periprocedural and at follow-up.
METHODS: From March 2012 to December 2014, 391 consecutive patients underwent TAVR (N.=290) or isolated SAVR (N.=101), concomitantly. Patients’ data were prospectively collected.
RESULTS: TAVR patients had more comorbidities. One (0.34%) TIA and 9 (3.11%) strokes occurred in-hospital following TAVR, but no cerebrovascular event occurred after SAVR (P=0.11). One stroke (0.99%) and one TIA (0.99%) were detected in SAVR group within 30 days. Among TAVR patients, one (0.75%) stroke at 6 months, 2 (1.9%) strokes and 2 (1.9%) TIAs at 12 months were diagnosed. Kaplan-Meier analysis revealed that 96% and 99% 12-month CVA free survival following TAVR and SAVR, respectively (P=0.67). Preoperative mean trans-aortic valve systolic pressure gradient higher than 40 mmHg remained as risk factor for stroke in TAVR patients only, OR: 4.48 (CI: 1.2-16.54, P=0.02). One intraoperative death, and 5 (4 with CVA) in-hospital deaths occurred after TAVR; whereas only one patient died in SAVR group (P=0.49). Thirty-day mortality was 3.8% (11/290) for TAVR and 0.99% (1/101) for SAVR patients. SAVR patients’ survival was 99% at 6 months, 97.9% at 12, and 96.4% at 24 months, whereas survival in TAVR was 97.5% at 6, 92% at 12, and 73.6% at 24 months (HR: 8.43 (CI: 2.47-28.73), P<0.001).
CONCLUSIONS: Even with significant differences in patients’ baseline characteristics; in-hospital and mid-term stroke rates are not significantly higher following TAVR than SAVR. Although periprocedural stroke is not uncommon in TAVR, mid-term stroke rate is low.


KEY WORDS: Stroke - Transcatheter aortic valve replacement - Outcomes assessment (health care)

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