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REVIEWS  NEW DEVELOPMENTS WITH DRUG-ELUTING BALLOONS 

The Journal of Cardiovascular Surgery 2016 February;57(1):12-7

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Drug-coated balloons: what is the evidence?

Leonardo MARQUES, Silke HOPF-JENSEN, Stefan MÜLLER-HÜLSBECK

Institute of Radiology and Neuroradiology, Ev.-Luth. Diakonissenanstalt zu Flensburg, Flensburg, Germany


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Having evolved at a rapid pace, the therapy options for percutaneous treatment of peripheral arterial disease in the lower limbs, especially percutaneous transluminal angioplasty in combination with stent-technology, are able to deliver a rate where at least 80% of the treated patients remain free from reintervention after the first years under ideal study conditions, meaning that defined and often restrict in- and exclusion criteria were fulfilled and mid-term dual platelet therapy is warranted. This is somewhat a huge leap when compared to the 50-60% in the 1980s and 1990s, but we now face an era of an increasingly demanding clientele, where the industry also strives to cover this final 20% with newer technologies. As recent studies with drug-eluting stents (DES) suggests, nowadays it is possible to achieve up to 90% patency in the short- and mid-term, but this comes accompanied by remarkably increased therapy costs, making it almost impossible to most centers to implant it as the standard therapy option. Trying to fill this gap between the low-patency of the plain old balloon angioplasty and the higher costs of the DES, drug-coated balloon technology has found its niche, knowing that reimbursement shows a broad variation across the countries and continents.

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