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REVIEWS  DRUG-ELUTING TECHNOLOGIES: WHERE ARE WE 

The Journal of Cardiovascular Surgery 2011 April;52(2):235-43

Copyright © 2011 EDIZIONI MINERVA MEDICA

language: English

Drug-coated balloons in the lower limb

Zeller T. 1, Schmitmeier S. 2, Tepe G. 3, Rastan A. 1

1 Angiology Division, Heart Center, Bad Krozingen, Germany; 2 InnoRa GmbH, Berlin, Germany; 3 Institute for Diagnostic and Interventional Radiology, Rosenheim Hospital, Rosenheim, Germany


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Even if recently the first positive results were presented for a paclitaxel releasing drug eluting stent there are still concerns about stent implantation in the femoro-popliteal artery. This makes any stentless technology attractive that achieves at least as good acute and longer term results in this vessel area. Three randomized studies investigating the value of short time paclitaxel release using a drug coated balloon gave promising results with significantly improved patency rates compared to plain balloon angioplasty in femoro-popliteal lesions and at least as good patency results as for the majority of bare metal nitinol stents (THUNDER, FEMPAC, LEVANT 1). Below-the-knee this promising concept is still under evaluation (PICCOLO study) whereas the first positive results for drug eluting stents in shorter lesions had been recently presented (YUKON BTK, DESTINY). This article gives an overview upon already published and presented data and still ongoing trials on drug releasing balloons in the peripheral arteries.

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