Home > Journals > The Journal of Cardiovascular Surgery > Past Issues > The Journal of Cardiovascular Surgery 2010 June;51(3) > The Journal of Cardiovascular Surgery 2010 June;51(3):449-56

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe PROMO
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Reprints
Permissions

 

REVIEW  CARDIAC SECTION 

The Journal of Cardiovascular Surgery 2010 June;51(3):449-56

Copyright © 2010 EDIZIONI MINERVA MEDICA

language: English

Human or animal homograft: could they have a future as a biological scaffold for engineered heart valves?

Dainese L., Biglioli P.

Department of Cardiac Surgery, University of Milan, Centro Cardiologico Monzino IRCCS, Milan, Italy


PDF


Tissue-engineered heart valves (TEHVs) promise to be the ideal heart valve replacement: they have the potential to grow and repair within the host, to minimise inflammatory and immunological responses and to limit thromboembolism. Viable cells included in TEHVs can theoretically adapt to a growing and changing environment exactly as a native biological structure. This could be extremely important in case of paediatric applications, where reoperations are frequently required to replace failed valve substitutes or to accommodate the growth of the patient. At present time the biological matrix from allogenic or xenogenic decellularized valves represents an appropriate valve scaffold in TEHVs, showing theoretically an ability to grow and repair within the host. Viable cells included in extracellular valve matrix can theoretically adapt to a growing and changing environment like the native biological structure. The aim of this paper is to present a review concerning the use of homograft and allograft valves as an ideal substrate for cardiac engineered tissue valves that represent an exciting possibility for in situ regeneration and repair of heart valves.

top of page