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The Journal of Cardiovascular Surgery 2003 February;44(1):125-9

Copyright © 2009 EDIZIONI MINERVA MEDICA

language: English

The importance of the time interval between diagnosis and operation in myasthenia gravis patients

Dural K., Yildirim E., Han S., Özisik K., Ulasan N., Saygin H., Sakinci Ü.

Department of Thoracic Surgery Ankara Numune Education and Research Hospital Ankara, Turkey


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Aim. Com­plete remis­sion ­rates in ­patients ­with myas­thenia ­gravis (MG) ­using anti­cho­line este­rases, immu­no­sup­pres­sive ­drugs, and med­ical ­therapy ­methods ­like plas­ma­pher­esis are low. ­Because ­high ­levels of com­plete remis­sion and advan­tages are ­reported ­after thy­mec­tomy ­this sur­gical ­method is ­widely ­used in ­patients ­with MG.
­Methods. The pre­op­er­a­tive ­status and the ­responses to thy­mec­tomy ­have ­been ­studied in 15 ­patients who had ­been diag­nosed as MG and under­went thy­mec­tomy in ­Ankara ­Numune Edu­ca­tion and ­Research Hos­pital.
­Results. ­Patients who under­went thy­mec­tomy ­have ­shown a ­high pro­por­tion of clin­ical improve­ment (73%). We ­could not estab­lish a ­direct rela­tion­ship ­between the ­results and the ­patients’ age, sex fea­tures and the path­o­log­ical char­ac­ter­is­tics of the exci­sional ­biopsy spec­i­mens. The ben­efit ­rates for ­patients who had a ­short ­period of ­time ­between diag­nosis and oper­a­tion (87.5%) ­were ­higher (91%).
Con­clu­sion. Thy­mec­tomy ­because of its ­high ben­efit ­rate is an advan­ta­geous ther­a­peutic ­tool. The ­chance of ben­e­fiting ­from thy­mec­tomy ­increases ­when the his­tory of MG is ­short and the ­stage of the dis­ease is ­early.

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