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The Journal of Cardiovascular Surgery 2001 April;42(2):187-92

Copyright © 2009 EDIZIONI MINERVA MEDICA

language: English

The effect of Celsior solution on 12-hour cardiac preservation in comparison with University of Wisconsin solution

Mohara J., Takahashi T., Oshima K., Aiba M., Yamagishi T., Takeyoshi I., Matsumoto K., Morishita Y.

From the Second Department of Surgery Gunma University School of Medicine, Gunma *Department of Pathology Nippon Medical School Second Hospital Kanagawa, Japan


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Back­ground. Cel­sior is a new extra­cel­lular-­type pres­er­va­tion solu­tion ­which has ­been devel­oped to act not ­only as a ­storage ­medium but ­also as a per­fu­sion ­fluid ­during ­initial ­donor ­heart ­arrest, post­storage ­graft reim­plan­ta­tion and ­early reper­fu­sion. We ­designed ­this experi­mental ­study to eval­uate the ­effect of the Cel­sior solu­tion in com­par­ison ­with the Uni­ver­sity of Wis­consin solu­tion ­from the view­point of ­energy deple­tion.
­Methods. ­Adult mon­grel ­dogs ­weighing 9 to 13 kg ­were ­divided ­into two ­groups. In the UW ­group (n=7), a 4°C Uni­ver­sity of Wis­consin solu­tion was ­used for cor­o­nary vas­cular ­washout and ­storage fol­lowing car­diac ­arrest ­using a glu­cose-­insulin-potas­sium solu­tion. In the Cel­sior ­group (n=7), the Cel­sior solu­tion was ­used to ­obtain car­diac ­arrest, cor­o­nary vas­cular ­washout and ­storage. ­High ­energy phos­phate ­levels and myo­car­dial pH ­were meas­ured ­using 31P-­nuclear mag­netic res­o­nance spec­tros­copy imme­di­ately ­after pres­er­va­tion and at 3, 6 and 12 ­hours ­after pres­er­va­tion. ­After 12-­hour ­cold ­storage, ­left ven­tric­ular ­free ­wall tis­sues ­were har­vested for his­to­log­ical exam­ina­tion.
­Results. ­High ­energy phos­phate ­levels and myo­car­dial pH ­were sig­nif­i­cantly ­better pre­served in the Cel­sior ­group ­than in the UW ­group. In the his­to­log­ical find­ings, gly­cogen gran­ules ­were pre­served ­well in the Cel­sior ­group.
Con­clu­sions. We con­clude ­from our ­study ­that the Cel­sior solu­tion is com­par­able to the Uni­ver­sity of Wis­consin solu­tion for use in 12-­hour ­heart pres­er­va­tion in ­canine ­models.

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