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The Journal of Cardiovascular Surgery 1999 June;40(3):355-61

Copyright © 2000 EDIZIONI MINERVA MEDICA

language: English

Effects of coenzyme Q10 on myocardial protection during cardiac valve replacement and scavenging free radical activity in vitro

Zhou M., Zhi Q., TAng Y., Yu D., Han J.

From the Department of Cardiovascular Surgery China-Japan Friendship Hospital, Beijing * Department of Biophysics, China-Japan Friendship Institute of Clinical Medical Sciences, Beijing, China


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Back­ground. To eval­uate the ­effects of CoQ10 on myo­car­dial pro­tec­tion in ­patients under­going car­diac ­valve replace­ment and ­direct scav­enging ­free rad­i­cals ­activity in ­vitro.
­Methods. Twen­ty-­four ­patients ­were ran­domly ­divided ­into two ­groups. ­Twelve ­patients in the CoQ10 ­group ­received intra­ve­nous and intra­cor­o­nary CoQ10-­treated “­round the oper­a­tive ­period”. ­Twelve ­patients in the con­trol ­group ­received no CoQ10-treat­ment.
Meas­ures. ­Plasma mal­on­di­al­de­hyde (MDA) con­cen­tra­tion, eryth­ro­cyte super­oxide dis­mu­tase (SOD) ­activity, and ­serum car­diac iso­en­zyme of crea­tine ­kinase (CK-MB) ­were meas­ured in the per­i­op­er­a­tive and post­op­er­a­tive ­period. The ­effects of CoQ10 ­direct scav­enging ­free rad­i­cals ­were deter­mined ­with elec­tron ­spin res­o­nance (ESR) and ­spin-trap­ping tech­niques by an in ­vitro ­study.
­Results. ­Plasma MDA con­cen­tra­tion and ­serum CK-MB ­levels in the CoQ10 ­group ­were sig­nif­i­cantly ­lower ­than ­those in the con­trol ­group. Eryth­ro­cyte SOD ­activity in the CoQ10 ­group was sig­nif­i­cantly ­higher ­than ­that in the con­trol ­group. CoQ10 ­showed an ­obvious ­hydroxyl rad­ical scav­enging ­activity, but it ­could not scav­enge super­oxide ­anion rad­i­cals.
Con­clu­sions. ­These find­ings dem­on­strated ­that the use of intra­ve­nous and intra­cor­o­nary CoQ10-treat­ment may ­play a ­more ben­e­fi­cial pro­tec­tive ­role ­during car­diac ­valve replace­ment ­through its anti­ox­i­dant prop­er­ties and mem­brane sta­bil­iza­tion, as ­well as ­through its ­ability to scav­enge ­hydroxyl rad­i­cals ­directly.

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