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Acta Vulnologica 2015 March;13(1):25-36


language: English, Italian

Heterologous collagen in the treatment of non-healing ulcers of the lower limbs

Nebbioso G. 1, Petrella F. 2, Nebbioso V. 3

1 Azienda Sanitaria Locale Napoli 1 Centro, Naples, Italy; 2 Azienda Sanitaria Locale Napoli 3 Sud, 3 Corso di Laurea in Chimica e Tecnologie Farmaceutiche, Federico II University, Naples, Italy


In chronic wounds, skin (LCC), local conditions, problems related to vascular microcirculation, cell phones, preventing or slowing down the formation of the extracellular matrix is temporary or permanent, delaying the formation of the network where they go to connect the different cell types involved in the process of cellular repair. Collagen type II intervenes in its own right, at all stages of the healing mechanism of LCC, carrying out hemostasis, chemotaxis, angiogenesis, fibroblast and restorative. In the literature, many studies show that the application of collagen can positively influence the formation of the extracellular matrix. The heterologous collagen plays a mechanical action filling by replacing the loss of tissue promoting, simultaneously, the anchor, the orientation of the fibroblasts and collagen synthesis ex-novo and favoring angiogenesis with formation of granulation tissue. Both the state of the injury that the type of injury can affect the effectiveness of the product used, this different behavior leads to the hypothesis that individual products that affect the extracellular matrix, to be selected by also assessing the etiology of lesion. The purpose of this clinical study is to evaluate the ability of the equine collagen to perform a positive action on the process of tissue repair in chronic skin lesions from other causes, to a group treated with hyaluronic acid. In the treatment of ulcers vasculitic and mixed there has been more effective against collagen hyaluronic acid compared to a substantial overlap of results in other typical lesion.

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