ORIGINAL ARTICLE   

Acta Phlebologica 2018 December;19(3):87-90

DOI: 10.23736/S1593-232X.18.00419-8

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

F11 gene polymorphism in patients with vein thrombosis in the population of Latvia

Irina KAJUNA ¹ ✉, Helēna MIKAŽĀNE ², Valda STAŅĒVIČA ²

¹ Baltic Vein Clinic (BVC), Rīga Stradiņš University, Rīga, Latvia; ² Rīga Stradiņš University, Rīga, Latvia

BACKGROUND: Deep vein thrombosis (DVT) is the result of innate thrombotic tendency and nongenetic triggers. Recent studies have found an association between DVT and single nucleotide polymorphisms (SNPs) in a 4q35.2 locus that contains the gene encoding factor XI (F11), a cytochrome P450 family member (CYP4V2).
METHODS: The study group consisted of 99 DVT patients. The control group consisted of 99 individuals. We investigated the association of 8 SNPs genes F5 (rs6025), F2 (rs1799963), SELE (rs5361), SERPINC1 (rs2227589), FGG (rs20066865), CYP4V2 (rs13146272), F11 (rs2289252), GP6 (rs1613662) with DVT patients in Latvia.
RESULTS: We found that polymorphism of the F11 gene (rs2289252) was associated with an increased risk of DVT (OR=2.19, P=0.0004).
CONCLUSIONS: The F11 gene (rs2289252) polymorphism showed an association with VT in the Latvian population.

KEY WORDS: Single nucleotide polymorphisms - Thrombosis - Deep venous thrombosis