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Acta Phlebologica 2018 August;19(2):56-8

DOI: 10.23736/S1593-232X.18.00421-6

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Pilot study using bioimpedance to evaluate the treatment of arm lymphedema using diosmin and micronized hesperidin

José M. PEREIRA de GODOY 1 , Ana C. PEREIRA de GODOY 2, Rodrigo OCAMPOS TROITINO 3, Maria de Fatima GUERREIRO GODOY 4

1 Cardiology and Cardiovascular Surgery Department of the Medicine School in São José do Rio Preto (FAMERP), CNPq (National Council for Research and Development), São José do Rio Preto, Brazil; 2 Pediatric Faculty of Medical Sciences of Santa Casa de São Paulo and Researcher Group of the Clínica Godoy, São José do Rio Preto, SP, Brazil; 3 Resident of Service Family Medicine in Medicine, School of ABC-Santo Andre-São Paulo and Researcher Group of the Clínica Godoy, São José do Rio Preto, SP-Brazil do Rio Preto, Brazil; 4 Medicine School, São José do Rio Preto (FAMERP), São José do Rio Preto, Brazil



BACKGROUND: There is no consensus on a single therapy for the treatment of lymphedema, and thus a combination of therapies is recommended. The aim of this study was to evaluate the effectiveness of diosmin with hesperidin as monotherapy to reduce breast cancer-related lymphedema as assessed by bioimpedance.
METHODS: Thirteen patients aged from 46-57 years old (mean: 52.4 years) submitted to breast cancer treatment were evaluated in the Clinica Godoy in 2014 and 2016. All patients complained of swelling of the arm. Patients were included in this study if it was their first episode of swelling and edema was confirmed by bioimpedance (InBody S10). Diosmin and micronized hesperidin (Daflon®) were prescribed for one month after which the arm was again evaluated by bioimpedance. The paired t-test was used for statistical analysis with an alpha error of 5% being considered acceptable.
RESULTS: Significant reductions in limb volume were detected (paired t-test: P value <0.04).
CONCLUSIONS: The use of diosmin together with micronized hesperidin at the onset of breast cancer-related lymphedema can temporarily control the swelling.


KEY WORDS: Lymphedema - Therapeutics - Diosmin - Hesperidin - Breast neoplasms

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