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A Journal on Phlebology

Official Journal of the Italian College of Phlebology
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Acta Phlebologica 2014 August;15(2):49-55


language: English

Chronic venous ulceration of the lower limbs and thrombosis

De Franciscis S. 1, 2, Grande R. 1, Buffone G. 1, Serra R. 1, 2

1 Department of Medical and Surgical Science, Magna Graecia University, Catanzaro, Italy; 2 Interuniversity Center of Phlebolymphology, International Research and Educational Program in Clinical and Experimental Biotechnology, Magna Graecia University, Catanzaro, Italy


Chronic venous ulceration is a major complication of chronic venous disorder with important implications in terms of morbidity and social expenditure. Venous thrombosis and thrombophilia are widespread conditions, often associated with venous ulcers of the lower limbs. This link has not yet been widely described in the literature and aim of this work was to analyze the relationship between these two conditions reviewing the current literature. PubMed, Scopus and ScienceDirect databases were searched for articles using the terms: thrombophilia, venous ulceration, chronic venous disorders and the significant full text were downloaded and analyzed. From the literature review, a description of the most common thrombofilic abnormalities found in literature and the relationship with CVU was given. Conditions such as antithrombin deficiency, protein C deficiency, protein S deficiency, factor V Leiden, hyperhomocystinaemia, prothrombin G20210A mutation, antiphospholipid antibodies, elevated factor VIII levels, elevated factor XI levels, plasminogen activator inhibitor type 1 mutations, cancer, obesity, pregnancy and trauma through current literature were statistically linked to the presence of chronic venous ulceration. The main conclusion to be drawn from the available literature is that patients with chronic venous ulceration of the lower limbs appear to have a prevalence of thrombophilia and/or thromboembolic events that is much higher than in the general population.

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