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Otorhinolaryngology 2021 June;71(2):100-4

DOI: 10.23736/S2724-6302.20.02319-X

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Allergy as a contributing factor in chronic rhinosinusitis with nasal polyps: a prospective non-randomized controlled study

Seksun CHAINANSAMIT, Unchana RUKKID, Patorn PIROMCHAI

Department of Otorhinolaryngology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand



BACKGROUND: There are conflicting data regarding the association between allergy and chronic rhinosinusitis with nasal polyps (CRSwNP). The objective of this study was to determine whether an allergy is a contributing factor to CRSwNP.
METHODS: We conducted a prospective non-randomized controlled study comparing patients suffering from CRSwNP with participants who had no nasal symptoms. Both CRSwNP and non-CRSwNP participants underwent a skin prick test, and the odds ratio was calculated to determine the risk of having CRSwNP between those with positive and those with negative results.
RESULTS: There were 48 participants in this study with a mean age of 33.33 years. The skin prick test was positive in 15 CRSwNP patients (62.5%) and 8 participants in the control group (33.33%). The odds of having CRSwNP were 3.3 times higher in the positive skin test group than in the negative group (P=0.046, 95% CI 1.02 to 10.90).
CONCLUSIONS: This study found a strong relationship between allergy and CRSwNP and that allergy patients have a high risk of having CRSwNP.


KEY WORDS: Rhinitis, allergic; Nasal polyps; Allergy and immunology

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