CUTTING EDGE OTOLARYNGOLOGY 2013 

Otorinolaringologia 2013 March;63(1):27-38

Copyright © 2013 EDIZIONI MINERVA MEDICA

language: English

Role of Id1 and NF-κB in the pathogenesis of human aural cholesteatoma

Lin J. ¹, Ye S. ^{1, 2}, Hamajima Y. ¹, Narita N. ³, Jung T. T. K. ⁴

¹ Department of Otolaryngology Head and Neck Surgery University of Minnesota, MN, USA; ² Department of Otolaryngology Head and Neck Surgery, Fujian Medical University, Fuzhou, China; ³ Fukui Medical University, Matsuoka, Japan; ⁴ Loma Linda University, Loma Linda, CA, USA

Little is known about the pathogenesis of human aural cholesteatoma, the most aggressive and destructive non-neoplastic disease in the middle ear, epitymanum and mastoid. As a result, there is no effective medical treatment for this devastating disease besides surgical removal. In the recent years, some important progresses have been made in the research arena regarding the driving force for the keratinocyte hyperproliferation, migration, aggressiveness, and self renewal in the cholesteatomal matrix. In this review, we will focus on the key issues in the pathogenesis of cholesteatoma and discuss what is known about these issues, what is unknown, and what needs extensive studies in the future.