INTRATYMPANIC THERAPIES FOR INNER EAR DISORDERS 

Otorinolaringologia 2010 September;60(3):213-

Copyright © 2010 EDIZIONI MINERVA MEDICA

language: English

Techniques of intratympanic administration

Marchese D., Riggio F., Gallina S., Speciale R.

Division of Otolaryngology, Department of Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy

The purpose of this review is to examine the most recent literature regarding the application of transtympanic inner ear perfusion in the treatment of auditory and vestibular disfunction. Transtympanic delivery of medications to the inner ear has been a rapidly expanding field in otolaryngology, and clinically more relevant, with understanding of pharmacokinetics becoming more closely studied. Emerging therapy like nanoparticles and facilitators are being explored. Advanced therapy development will likely require direct intracochlear delivery . Potential uses for such devices include neurotrophic factors. Recent studies about nanotechnology and molecular therapy have pushed development of alternate delivery methodologies involving both transtympanic and direct intracochlear infusions.