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Italian Journal of Dermatology and Venereology 2021 Sep 21

DOI: 10.23736/S2784-8671.21.07089-4


language: English

Melanoma and hypertension, is there an association? A U.S. population based study

Amr E. EL-QUSHAYRI 1 , Amira Y. BENMELOUKA 2, Samar SALMAN 3, Beatrice NARDONE 4

1 Faculty of Medicine, Minia University, Minia, Egypt; 2 Faculty of Medicine, University of Algiers, Algiers, Algeria; 3 Department of Dermatology and Venereology, Faculty of Medicine, Tanta University Hospital, Tanta University, Tanta, Egypt; 4 Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA


BACKGROUND: Melanoma is one of the three major types of skin cancer. In this study we aimed to investigate the association between melanoma and hypertension comorbidity.
METHODS: We performed a population based study using NHANES database during the period 1999-2004. Data were analyzed using SPSS version 24.
RESULTS: Data for 12446 individuals of which 146 had a diagnosis for melanoma were extracted. Melanoma group were older than the no melanoma group as 51% of the melanoma group were 60 years or elder; however 53.6% of the no melanoma group falls below 30 years old. Melanoma group had higher frequency of hypertension (37%) compared to the no melanoma group (22.5%). Logistic regression revealed that melanoma patients had higher odds of hypertension prevalence using the unadjusted model (odds ratio (OR): 2.03, 95% confidence interval (CI): 1.45-2.84, p <0.001). However, after controlling of all potential confounding factors the significance was lost (OR: 0.89, 95% CI: 0.61-1.3, p = 0.54).
CONCLUSIONS: There may be a possible association of melanoma with hypertension comorbidity. With the limitations we faced, we encourage further research to confirm the association of melanoma and hypertension comorbidity.

KEY WORDS: Melanoma; Hypertension; Comorbidity

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