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Giornale Italiano di Dermatologia e Venereologia 2020 Apr 29

DOI: 10.23736/S0392-0488.20.06401-9


language: English

Capillaroscopy: a new application for the evaluation of vascular side-effects induced by chemotherapy

Michele CARDONE 1, Gemma CARO 1 , Beatrice AMOROSI 2, Antonio CRISTAUDO 2, Aldo MORRONE 2, Stefano CALVIERI 1, Marta CARLESIMO 1, Maria Caterina FORTUNA 1, Alfredo ROSSI 1

1 Department of Internal Medicine and Medical Specialties, “Sapienza” University of Rome, Rome, Italy; 2 Clinical Dermatology Department, S. Gallicano Dermatological Institute, IRCCS, Rome, Italy

BACKGROUND: Cancer survivors are rising up, but this better survival is accompanied by possible treatments side-effects. In particular, cardiovascular effects are commonly reported, even if vascular damage is not necessarily connected to clinical manifestations. Periungual microcyrcle evaluation through capillaroscopy could identify asymptomatic patients with high risk of cerebro-cardio- vascular disease. The aim of this pivotal study is to evaluate videocapillaroscopy in patients who undergo chemotherapy, in order to understand if it could represent in future a prognostic tool to predict the risk of cardio-cerebro-vascular events.
METHODS: We conducted an open-label, uncontrolled study. Patients affected by solid tumors were enrolled. Each subject underwent a clinical evaluation and a videocapillaroscopic examination.
RESULTS: We selected 25 patients. Mean age was 55.48 years. Time interval between the start of chemotherapy and capillaroscopy: average 41 months. From our analysis it emerges that ectasia and hemorrhages could be a possible markers of capillary insult caused by chemotherapy.
CONCLUSIONS: Our study shows the presence of capillaroscopic features that may be peculiar in chemotherapy-induced endothelial damage. The individuation of capillaroscopic alteration specific for chemotherapy-induced endothelial injury could be an important tool to identify patients with high cardiovascular risk.

KEY WORDS: Capillaroscopy; Chemotherapy; Vascular; Side effects

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