REVIEW   Free access

Giornale Italiano di Dermatologia e Venereologia 2020 December;155(6):719-23

DOI: 10.23736/S0392-0488.20.06551-7

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

What makes an inflammatory disease inflammatory? An overview of inflammatory mechanisms of allergic contact dermatitis, atopic dermatitis and psoriasis

Eleonora FARINAZZO ¹, Roberta GIUFFRIDA ² ✉, Caterina DIANZANI ³, Roberta VEZZONI ¹, Chiara RETROSI ¹ Nicola DI MEO ¹, Iris ZALAUDEK ¹, Claudio CONFORTI ¹

¹ Clinic of Dermatology, Maggiore Hospital, University of Trieste, Trieste, Italy; ² Section of Dermatology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy; ³ Section of Dermatology, Department of Plastic, Reconstructive and Cosmetic Surgery, Campus Bio-medico University Hospital, Rome, Italy

Inflammatory response in the skin is important for host defense against a broad spectrum of insults including microorganisms, chemicals, radiation and physical trauma. When the inflammatory process becomes prolonged and self-perpetuating, illness occurs. In this review, we discuss recent findings regarding the complex inflammatory mechanisms in allergic contact dermatitis, atopic dermatitis and psoriasis.

KEY WORDS: Psoriasis, Dermatitis, atopic; Dermatitis, allergic contact; Inflammation; Skin diseases