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ORIGINAL ARTICLE   

Giornale Italiano di Dermatologia e Venereologia 2019 December;154(6):624-31

DOI: 10.23736/S0392-0488.17.05592-4

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

The anti-inflammatory and antioxidant properties of 1,2-decanediol and willow bark extract in lipopolysaccharide-stimulated keratinocytes

Roberta DI CAPRIO 1 , Giuseppe MONFRECOLA 1, Anna BALATO 2, Nicola BALATO 1, Franco GASPARRI 3, Raffaella MICILLO 1, Serena LEMBO 4

1 Section of Dermatology, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy; 2 Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy; 3 Department of Pharmacy (DIFARMA), University of Salerno, Salerno, Italy; 4 Department of Medicine, Surgery, and Dentistry, “Scuola Medica Salernitana”, University of Salerno, Salerno, Italy



BACKGROUND: 1,2-Decanediol (S-Mal) is an organic compound belonging to the 1,2-alkanediol family, with two hydroxyl groups located on the first and second carbon of the alkane chain, probably responsible for the enhanced anti-bacterial efficacy. The willow bark total extract (W-Mal) has been used since thousands of years as an herbal remedy for its antipyretic, analgesic, anti-inflammatory and anti-microbial activities. S-Mal is used in cosmetic preparations, whether W-Mal can be topically or systemically administered. Aim of our study was to evaluate in vitro the anti-inflammatory and antioxidant properties of S-Mal and W-Mal, singularly or in combination, in LPS-stimulated keratinocytes.
METHODS: The possible toxic effect of S-Mal and W-Mal was assessed through analysis of cell viability 24 hours after treatment. The anti-inflammatory and antioxidant activities were evaluated by measuring IL-8, TNF-α and IL-1β production as well as cellular antioxidants (GSH and NADPH) consumption, 24 and 48 hours, respectively, after LPS stimulation.
RESULTS: Both substances resulted able to: 1) increase cell viability (P<0.05); 2) decrease the release of inflammatory mediators (IL-8, TNF-α and IL-1β) (P<0.05 - P<0.001); and 3) limit the depletion of cellular antioxidants (GSH and NADPH) (P<0.001).
CONCLUSIONS: S-Mal and W-Mal have shown a potential cytoprotective activity when used together, and good anti-inflammatory and antioxidant effects when used either singularly or in combination. In light of our results, S-Mal and W-Mal could represent effective and safe options in the management of bacterial-induced or aggravated skin conditions.


KEY WORDS: 1,2-decanediol; Anti-inflammatory agents; Antioxidants; Salix

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