ORIGINAL ARTICLE   

Giornale Italiano di Dermatologia e Venereologia 2019 February;154(1):6-13

DOI: 10.23736/S0392-0488.18.06104-7

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Evaluation of tolerability and skin changes after application of topical antiaging products based on Sibanid SG®, plant stem cells and regenerative and biostimulating active ingredients

Mirella D’ANDREA ✉, Anna PERROTTA, Maria FERRILLO, Mariateresa CANTELLI, Marianna DONNARUMMA, Gabriella FABBROCINI

Unit of Dermatology, Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy

BACKGROUND: The oxidative stress, the UV radiations, the matrix metalloproteinases (MMPs) and the hyaluronidase enzyme play an extremly important role in skin aging processes, leading an increasing production of elastase, collagenase and hyaluronidase that brings to degradation of collagen, elastin and hyaluronic acid respectively. They are responsible to provide strength, elasticity and moisture to the skin. Innovative devices were developed based on the effective ingredients against hyaluronidase and MMP. The inhibition of the destructuring enzymes of the dermis is the main mechanism of action of Bioliftan treatment, and this process is mainly addressed to hyaluronidase and MMP inhibition. The aim of our study was to evaluate the efficacy, tolerability and skin changes induced by antiaging topical based on Sibanid SG®, plant stem cells and regenerative and biostimulating active ingredients. The products tested are Bioliftan Day cream and Bioliftan concentrate.
METHODS: All parameters were evaluated before the beginning of treatment (T0), and 60 (T1) days later. The evaluation of the effectiveness of the products was performed by clinical examination, photographic and instrumental documentation by corneometry, X-rite, elastometry, Moisture Meter EpiD, Confocal microscopy.
RESULTS: The products tested after 60 days have induced an increase of hydration of the external cutaneous layers (P<0.0001), skin hydration (P<0.0001), skin brightness (P<0.01), skin elasticity (P<0.0001). All results were statistically significant. All volunteers completed the study. No patients reported side-effects. All results were confirmed by confocal microscopy.
CONCLUSIONS: Our study evaluated efficacy, tolerability and skin changes after 60 days of Bioliftan day cream and Bioliftan serum concentrate application on the skin aged. Our study has shown an excellent skin tollerance of the products tested.

KEY WORDS: Skin aging - Administration, topical - Skin cream