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ORIGINAL ARTICLE   

Giornale Italiano di Dermatologia e Venereologia 2018 December;153(6):866-71

DOI: 10.23736/S0392-0488.18.05710-3

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Novel combination for the treatment of acne differentiated based on gender: a new step towards personalized treatment

Ersilia TOLINO , Nevena SKROZA, Alessandra MAMBRIN, Nicoletta BERNARDINI, Sara ZUBER, Veronica BALDUZZI, Anna MARCHESIELLO, Ilaria PROIETTI, Concetta POTENZA

“Daniele Innocenzi” Unit of Dermatology, Department of Medical-Surgical Science and Biotechnologies, Sapienza University of Rome, A. Fiorini Hospital, Terracina, Latina, Italy



BACKGROUND: The aim of this study is to evaluate efficacy and tolerability of a complete skin care line consisting of an oral supplement in two distinct formulations for males and females, and a topical cream device in the treatment of mild and moderate acne. Oral supplements contain biotin, probiotic, vitamin E, zinc, nicotinamide; in the formulation for males beta sitosterol and Boswellia serrata were added, the oral supplement for females contains myo-inositol and folic acid. The topical cream device is represented by the association between active plant agents (verbascoside, Ocimum gratissimum) and keratolytic molecules (salicylic acid, gluconolactone, complex alpha-hydroxy acids).
METHODS: An equal number of male and female patients with mild to moderate acne were enrolled in a double-blinded clinical trial. Efficacy and tolerability evaluations were performed at week 4 (T1) and week 12 (T2) by Global acne Grading System (GAGs).
RESULTS: Most of patients had satisfactory therapeutic response, in terms of GAGs reduction. All the four groups presented a statistically significant improvement of the mean GAGs at T2 but those assuming the oral supplement improved more, as expected.
CONCLUSIONS: Our data suggest that this association can be considered a new effective option for mild and moderate acne. This therapeutic line differs from others in the gender matched oral treatment.


KEY WORDS: Acne vulgaris - Administration, topical - Dietary supplements

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