SKIN INVOLVEMENT IN CONNECTIVE TISSUE DISEASES 

Giornale Italiano di Dermatologia e Venereologia 2014 October;149(5):483-503

Copyright © 2014 EDIZIONI MINERVA MEDICA

language: English

Cutaneous manifestations of rheumatic diseases. Clinical presentation and underlying pathophysiology

Gkogkolou P., Luger T. A., Böhm M. ✉

Department of Dermatology, University of Münster, Münster, Germany

Being the largest organ of the human body, skin is frequently affected in many rheumatic diseases. Thus, it can serve as an important indicator for the correct diagnosis of a rheumatic disease and also as a marker of disease activity in distinct rheumatic disorders. In this review we will highlight the clinical features of these cutaneous manifestations of the major rheumatic diseases. We will also provide an update on the complex pathobiology of these diseases based on the most recent developments in clinical and translational research.