PEARLS IN DERMATOLOGY 

Giornale Italiano di Dermatologia e Venereologia 2011 October;146(5):397-424

Copyright © 2011 EDIZIONI MINERVA MEDICA

language: English

Systemic drugs in patients with skin diseases

Byekova Y. A. ¹, Hughey L. C. ², Elewski B. E. ² ✉

¹ University of Alabama School of Medicine, Birmingham, AL, USA; ² Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA

Systemic drugs play an important role in the modern practice of dermatology. The purpose of this article is to review systemic therapies in the following categories: antifungals, immunosuppressants, retinoids, and biologic immunomodulators. We provide a historical perspective, summarize current clinical indications, and discuss novel mechanisms of action for each drug. Suggestions for dosing regimens and laboratory monitoring are given. To help clinicians safely implement these therapies in their practice, we review major adverse reactions and clinically important drug interactions of these systemic medications in dermatology.