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Giornale Italiano di Dermatologia e Venereologia 2008 February;143(1):15-9
Copyright © 2008 EDIZIONI MINERVA MEDICA
language: English
The regulatory T-cell phenotype in progressive mycosis fungoides
Hallermann C. 1, Schulze H. J. 1, Neumann C. 2, Klemke C. D. 3
1 Department of Dermatology Fachklinik Hornheide, Munster, Germany 2 Department of Dermatology University of Goettingen, Goettingen, Germany 3 Department of Dermatology, Venereology and Allergology University Medical Center Mannheim Ruprecht-Karls-University of Heidelberg Mannheim, Germany
In early stages mycosis fungoides (MF) often runs an indolent course. Nevertheless a small but significant part of these patients develop an aggressive, life threatening course. These patients usually were immunocompromised. In most of those cases the lymphoma cells express CD25. This raised the question if those lymphomas may express a regulatory phenotype. Recently a couple of in vitro and in vivo studies analyzed this issue with different methods. This review discusses the recent developments in this highly topical area of research.