REVIEWS   

Giornale Italiano di Dermatologia e Venereologia 2007 June;142(3):251-8

Copyright © 2007 EDIZIONI MINERVA MEDICA

language: English

Ultraviolet induced immune suppression a brief review

Santo Domingo D. ^{1, 2, 3}, Yang M. F. ^{1, 3, 4}, Cooper K. D. ^{1, 2, 3, 4, 5}, Baron E. D. ^{1, 2, 3, 4, 5}

¹ Department of Dermatology School of Medicine, Cleveland, OH, USA 2 The Case Skin Diseases Research Center Cleveland, OH, USA 3 Louis-Stokes VA Medical Center, Cleveland, OH, USA 4 Murdough Family Center for Psoriasis Case Western Reserve University/University Hospitals of Cleveland, Cleveland, OH, USA 5 The Case Comprehensive Cancer Center Cleveland, OH, USA

Ultraviolet (UV) light is known to cause several undesirable effects including premature aging, carcinogenesis and immune suppression. The immune response to UVB and UVA radiation involves an intricate network of cells, cytokines and signaling pathways. This review outlines some of the current research and key cellular components involved in UVB and UVA induced immune suppression as a result of either environmental or therapeutic exposure.