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Giornale Italiano di Dermatologia e Venereologia 2003 December;138(6):491-7

Copyright © 2003 EDIZIONI MINERVA MEDICA

language: Italian

Localized sclerodermia. Immunological aspects and clinical pictures

Bongiorno M. R., Pistone G., Malleo F., Aricò M.

Unità operativa complessa di Dermatologia e MTS Cattedra di Dermatologia Università degli Studi di Palermo, Palermo


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Localized scleroderma is a relatively benign well-circumscribed lesion and is characterized by round and/or oval irregular linear plaques. The localized scleroderma is a connetive tissue disorder usually limited to the skin and subcutaneous tissue. Raynaud’s phenomenon and systemic organ involvement are absent in localized scleroderma. The localized scleroderma is a spectrum which encompasses several clinical variants. The diagnosis of morphea is usually clinical and may be confirmed by skin biopsy. Localized scleroderma has been reported to be accompanied by various immunological abnormalities, such as antinuclear antibodies and anti-single-stranded DNA antibodies. The major antigens recognized by ANA in this disease are nuclear histones. Localized morphea, furthermore, is associated with increased levels of activation of CD4+ and CD8+ cells. Some major T-cell functions are mediate through release of a variety of lymphokines. The existence of a complex network of interacting cytokines mediate immune and inflammatory reactions in the skin. Fibroblasts, endothelial cells and keratinocytes participate actively and mutually in this network.

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