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Giornale Italiano di Dermatologia e Venereologia 2001 December;136(6):445-8

Copyright © 2001 EDIZIONI MINERVA MEDICA

language: Italian

Angiolymphoid hyperplasia with eosinophilia. A case report

Di Lernia V., Bonci A., Serra L., Lo Scocco G., Bisighini G.

Azienda Ospedaliera di Reggio Emilia Arcispedale Santa Maria Nuova Unità Operativa di Dermatologia * Servizio di Anatomia Patologica


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Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare, benign disorder of unknown etiology. It commonly occurs between the third and the fifth decades with slight dominance in females, presenting as papules or nodules on the head and neck, without lymphadenopathy and with mild peripheral eosinofilia. The main histological feature is proliferation and swelling of the endothelial cells, accompained by an infiltrate of lymphocytes and eosinophils. A case of ALHE in a 47 year-old man presenting an asymptomatic erythematous nodule and two papules on the forehead is reported. The nodular lesion was resected and histologic examination showed typical features of ALHE. After one year follow-up, no relapse was observed and the two papular lesions appeared unchanged. Etiology of ALHE and its relationship with Kimura’s disease are discussed. Actually ALHE and Kimura’s disease are considered different entities.

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