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Giornale Italiano di Dermatologia e Venereologia 2000 December;135(6):683-6

Copyright © 2000 EDIZIONI MINERVA MEDICA

language: Italian

CD30+ primary cutaneous large T-cell lymphoma associated with small plaque parapsoriasis

Gambini D., Ghislanzoni M., Alessi E., Berti E.

Università degli Studi - Milano e Milano Bicocca* IRCCS Ospedale Maggiore - Milano * Ospedale S.Gerardo - Monza (Milano)


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A rapidly growing CD30+ primary cutaneous large T-cell lymphoma of the left thumb observed in a 55 year man with a not diagnosed small plaque parapsoriasis on the trunk lasting for one year is described. The molecular analysis by PCR demonstrated a clonal rearrangement of the T-cell receptor g from DNA obtained from the lymphoma, but not from the peripheral blood and from parapsoriatic skin. Routine blood analysis, abdominal echotomography, bone marrow biopsy, abdominal and thoracic TAC were all negative. A complete regression of the lymphoma was achieved by local radiation therapy. The association between parapsoriasis and CD30+ primary cutaneous large T cell lymphoma is very unusual but not surprising because both entities are usually expression of CD4+ lymphocytes proliferation and therefore they can be considered as belonging to the same disease spectrum.

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