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Latest perspective in OAB treatment


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Overactive bladder (OAB) is a clinical syndrome characterized by troublesome symptoms namely urgency, often with urinary incontinence, frequency and nocturia. Although the condition is not life threatening, it induces a great negative impact on patients' quality of life and produces a plethora of healthcare concerns, with consequent, marked costs for the health systems. Despite the difficulties, science does not stop and research in the molecular, clinical, and technological fields continues, outlining a horizon full of new possibilities. On a physio pathological point of view the good news appears to be patient phenotyping according to the presence of different cofactors playing an important role on the development and course of the disease, and possibly, on the response to treatment. Patients' phenotyping will have necessarily to induce the physicians to change their attitude towards affected patients, using a broader view, outside the boundaries of the bladder and urethra. And apart from the well-known and currently applied treatments, there are more therapies coming out. With regards to pharmacological agents, new B3-AR agonists, novel TRPV1 inhibitors and P2X3 antagonists, and cannabinoid receptor agonists are currently under investigation in both pre-clinical and clinical studies. Among new technologies, several tibial nerve stimulators are in development, and different organ stimulation are being realizing; also, new delivery systems are under investigation to improve intravesical drug administration, and radiofrequency devices therapy appears to be an exciting treatment possibility.


Pathophysiology of OAB and refractory conditions

Antonella Giannantoni

Overactive bladder: cost-effectiveness of pharmacological treatment

Konstantinos Giannitsas, Anastasios Athanasopoulos

Second-line treatments for idiopathic and neurogenic OAB: clinical evidence for a better choice

Roberto Carone, Enrico Ammirati, Alessandro Giammò

OAB after surgical correction of female stress urinary incontinence

Elisabeth M. Sebesta, Roger R. Dmochowsky

OAB after reconstructive surgery for pelvic organ prolapse

Eleonora Russo, Giulia Misasi, Koray Gorkem Sacinti, Maria Magdalena Montt Guevara, Veronica Tomatis, Tiziana Fidecicchi, Tommaso Simoncini

OAB in people with special needs

Marilena Gubbiotti, Emanuele Rubilotta, Matteo Balzarro

The impact of OAB on female sexuality

Francesca Vedovo, Emanuele Rubilotta, Marilena Gubbiotti, Matteo Balzarro

OAB and UTIs: a solidarity menage

Luca Gemma, Alice Bonutto, Vincenzo Li Marzi

OAB and painful bladder: twin rivers from one spring?

Vasileios Sakalis, Sotirios Gatsos, Apostolos Apostolidis

Management of overactive and underactive bladder

Emanuele Rubilotta, Marilena Gubbiotti, Matteo Balzarro

OAB and sleep disturbance: a nightmare couple

Philip E.V. Van Kerrebroeck

OAB in frail older adults

Maria Angela Cerruto, Alessandro Tafuri

Er-YAG laser treatment of OAB

Marco Gambacciani, Peter Nobuo Okui


Antonella Giannantoni

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