Home > Books > Medicine > Internal medicine > Alpha1-antitrypsin and its targets


Alpha1-antitrypsin and its targets


Paperback € 30,00  € 28,50

eBook (ePub)  € 30,00

Add to basket   Preview   Email alert   


Over the past decade, it has been demonstrated that Alpha1-Antitrypsin (AAT) is a broad-spectrum anti-inflammatory, immunomodulatory, anti-infective and tissue-repair molecule. As a consequence, Alpha1-Antitrypsin Deficiency is a fascinating condition, affecting people at all ages, from neonates to the elderly, that requires multidisciplinary approaches. A greater understanding of the science underpinning pathophysiological mechanisms is now directly translating into an increasing number of clinical studies, new pharmacological formulations, new patent applications and the search for alternative sources of AAT to meet the expected demand for treating a large number of diseases, inside and outside the context of AAT deficiency. Medical professionals need an updated and intelligible text to discover and approach it in all the aspects of its manifestations, to properly suspect, diagnose, manage and treat it.


Alpha1-antitrypsin deficiency: pathophysiology and clinical aspects

Martina Meocci, Behar Cekorja, Elena Bargagli

Diagnosis of AATD: when to suspect and how to test

Ilaria Ferrarotti, Valentina Barzon, Alice M. Balderacchi

When “rare” does not mean “infrequent”

Stefania Ottaviani, Alessandra Corino

General management of lung disease: patient monitoring

Anna Annunziata, Sara Spinelli, Ediva Myriam Borriello, Giuseppe Fiorentino

Treatment perspective: when to start and personalize therapy

Luciano Corda

Pulmonary rehabilitation and lung transplantation

Bruno Balbi

Alpha1-antitrypsin deficiency and severe asthma

Gabriella Guarnieri, Sara Lococo, Alessia Achille, Andrea Vianello

Alpha1-antitrypsin deficiency and bronchiectasis

Mattia Nigro, Ana Lleo, Stefano Aliberti

Alpha1-antitrypsin deficiency and COVID-19

Angelo G. Corsico

Clinical manifestations in the liver

Federica Benini

Presentation of the alpha1-antitrypsin deficiency algorithm

Angelo G. Corsico, Ilaria Ferrarotti

Alpha1-antitrypsin deficiency and bronchiectasis: a clinical case. Is there a link?

Alessandro Sanduzzi Zamparelli, Stefano Sanduzzi Zamparelli

Clinical case presentation

Mario Torrazza, Stefano Del Giacco

The importance of a correct and comprehensive diagnosis in alpha1-antitrypsin deficiency

Davide Piloni, Silvia Mancinelli, Ilaria Ferrarotti, Angelo G. Corsico

The future of research: the EARCO Registry

Marc Miravitlles

Patient empowerment: home therapy and self-administration

Nuccia Gatta

top of page