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ITALIAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Rivista di Chirurgia Vascolare ed Endovascolare


Official Journal of the Italian Society of Vascular and Endovascular Surgery
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Italian Journal of Vascular and Endovascular Surgery 2014 December;21(4):201-4

lingua: Inglese

Directional atherectomy and adjunctive drug-coated balloon angioplasty

Sixt S. 1, Zeller T. 2

1 Angiologikum, Center for Interventional Angiology, Medical Care Prof. Mathey/Prof. Schofer, Hamburg, Germany;
2 University Heart Center, Freiburg Bad Krozingen, Bad Krozingen, Germany


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The safety and efficiency of directed atherectomy (DA) have consistently been demonstrated in multiple clinical trails. The mechanical excision of the intima, however, seems to induce a reasonable inflammatory response which limit the long term clinical benefit. To control this inflammatory process it has been proposed to apply antiproliferative drugs, via a paclitaxel coated balloon (DCB). The combination of DA and consecutively DCB has the potential to provide optimal vessel preparation and to improve drug uptake during balloon angioplasty.

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