I TUOI DATI
I TUOI ORDINI
N. prodotti: 0
Totale ordine: € 0,00
I TUOI ABBONAMENTI
I TUOI ARTICOLI
THE JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
Rivista di Medicina, Traumatologia e Psicologia dello Sport
Indexed/Abstracted in: Chemical Abstracts, CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,111
The Journal of Sports Medicine and Physical Fitness 2017 Feb 21
Copyright © 2017 EDIZIONI MINERVA MEDICA
Effects of exercise on learning and memory, oxidative stress and nNOS expression in marginal division of striatum of the ovariectomized rats
Jianmei CUI 1, Yanlan GUO 1, Wenyan YANG 1, Xingrui ZHAO 1, Fang YU 1✉, Wei TANG 1, Bianhua PANG 2, Xiaoyun SU 3
1 Physical Institute, North University of China, Taiyuan Shanxi, China; 2 Shanxi Research Institute of Science, Taiyuan Shanxi, China; 3 Department of Nursing Humanities Teaching and Research Section, Fenyang College of Shanxi Medical University, Fenyang Shanxi, China
BACKGROUND: Since previous studies have shown that ovariectomy impairs memory and cognition, we investigated whether 8-week treadmill exercise would affect ovariectomy-induced memory deficits and explore the possible mechanisms of physical exercise influencing spatial learning and memory of the ovariectomized rats by detecting the rat’s brain free radical metabolism and counting nNOS expression in marginal division of the striatum(MrD).
METHODS: 40 female rats were assigned to one of the following groups: SHAM, SHAM+E, OVX and OVX+E group. The rats of SHAM and OVX group kept normal activities and the SHAM+E and OVX+E group rats undertook a 8-week training with progressively increasing load. Then the cognitive function was evaluated using 8-arms radial maze test. Also, oxidative stress markers in the MrD were also evaluated and the nNOS expression in Mrd was detected and analysised.
RESULTS: Results show that ovariectomized rats were impaired in learning and memory and brain SOD (superoxide dismutase), CAT (catalase) activities were dropped and MDA (malondialdehyde) level increased via ovariectomy, nNOS expression in MrD was reduced in comparision with the SHAM group rats. While treadmill exercise significantly alleviated learning and memory decline and prevented brain oxidative damage induced by ovariectomy, nNOS expression in MrD significantly enhanced.
CONCLUSIONS: These findings support ovariectomy can impair spatial learning and memory of the rats, the regular treadmill exercise appears to exert a protective effect against ovariectomy -induced spatial memory impairment through inhibition of oxidative stress and up-regulation MrD nNOS expression.
KEY WORDS: Treadmill exercise - Ovariectomy - Eight-arm maze test - Oxidative damage - nNOS