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THE JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
Rivista di Medicina, Traumatologia e Psicologia dello Sport
Indexed/Abstracted in: Chemical Abstracts, CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,111
The Journal of Sports Medicine and Physical Fitness 2016 Jul 13
Effect of moderate or high intensity exercise on hypothyroid rats exposed to acute stress
Özgür KASIMAY ÇAKIR 1, Dilek ÖZBEYLI 1, Ebru ŞENEL 1, Gazi CONTUK 2, Ayliz VELIOĞLU ÖĞÜNÇ 3, Şule ÇETINEL 2, Berrak Ç. YEĞEN 1 ✉
1 Departments of Physiology, Marmara University School of Medicine, Ust Kaynarca, Pendik, Istanbul, Turkey; 2 Histology and Embryology, Ust Kaynarca, Pendik, Istanbul, Turkey; 3 Vocational School of Health Related Professions, Medical Laboratory Program, Ust Kaynarca, Pendik, Istanbul, Turkey
BACKGROUND: There are contradictory results about stress response in hypothyroidism and in exercising ones with variant intensities. We aimed to investigate the potential anxiolytic and protective effects of different intensities of exercise on acute psychological stress in hypothyroidism.
METHODS: Rats (n= 48) were divided as sedentary, moderate intensity (MIE) and high intensity exercise (HIE) groups. Rats were administered intraperitoneally with 6-n-propyl-2- thiouracil (PTU, 10 mg/kg) for 15 days to induce hypothyroidism. Starting by the 3rd week, treadmill exercise was performed moderately (30 min/day) or at high intensity (60 min/day) for 6 weeks, 5 days/week. At the end of the 8th week, exposure to water avoidance stress was used for induction of acute stress. Anxiety-like behavior was determined by holeboard test before and after stress inductions. Serum IL-1β and IL-6 assays, and myeloperoxidase activity (MPO), malondialdehyde (MDA), and glutathione (GSH) measurements, and histological analysis of heart, liver, stomach and small intestine were made.
RESULTS: All groups showed increased anxiety-like behavior following acute stress induction. After acute stress induction, increased MPO and MDA levels in heart and elevated MPO activity in liver were inhibited in PTU-treated HIE group. In MIE rats, increased MPO and declined GSH levels of the gastric tissue and small intestine, and elevated MDA levels of gastric tissue were reversed in PTU-treated MIE group. Major histological changes that occurred by both intensities of exercise under stress condition were improved by PTU.
CONCLUSION: Our results indicate that hypothyroid state may be protective against stress- and exhaustive exercise-induced oxidative damage.