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The Journal of Sports Medicine and Physical Fitness 2016 Jul 06

lingua: Inglese

HOMA-AD: the role of different types of physical exercise in obese adolescents

Raquel M. CAMPOS 1, 2, Deborah C. MASQUIO 2, Flávia C. CORGOSINHO 2, Priscila DE LIMA SANCHES 2, Aline DE PIANO 3, June CARNIER 2, Patrícia L. DA SILVA 4, Ana P. CLEMENTE 5; Sofia E. VICENTE 2, Lila M. OYAMA 2, Claudia M. DO NASCIMENTO 2, Lian TOCK 6, Sergio TUFIK 7, Marco T. DE MELLO 2, 7, 8 , Ana R. DÂMASO 2

1 Department of Physiotherapy, Therapeutic Resources Laboratory, Federal University of São Carlos (UFSCar), São Carlos, Brazil; 2 Post Graduate Program of Nutrition, Federal University of São Paulo (UNIFESP), Brazil; 3 University Center São Camilo (CUSC), Brazil; 4 Federal University of Goiás (UFG), Brazil; 5 Federal University of Alagoas, Brazil; 6 Weight Science, Brazil; 7 Psychobiology Department, Federal University of São Paulo (UNIFESP), Brazil; 8 School of Physical Education, Physiotherapy and Occupational Therapy, Federal University of Minas Gerais (UFMG), Brazil


BACKGROUND: Homeostasis Model Assessment-Adiponectin (HOMA-AD) is suggesting a new biomarker of insulin resistance in obese population. In this way, the purpose of this study was to investigate the effects of different kinds of exercise in the sensitive index predictor of insulin resistance.
METHODS: A total of 148 obese adolescents were enrolled in the program. They aged 15- 19y, with body mass index (BMI) ≥ P95th and were submitted to 1 year of interdisciplinary weight loss therapy, randomized in two groups, aerobic training (n=51) and aerobic plus resistance training (n=97). Blood samples were collected to analyze adiponectin, glucose and insulin concentrations. The insulin resistance was measured by Homeostasis Model Assessment-Adiponectin (HOMA-AD) and Homeostasis Model Assessment Insulin Resistance Index (HOMA-IR).
RESULTS: Both kinds of exercise training promoted a decrease in body mass, body mass index, fat mass, visceral and subcutaneous fat. However, only aerobic plus resistance training was effective to reduce HOMA-AD, insulin and glucose concentration; and increase insulin sensibility and adiponectin concentration.
CONCLUSIONS: The aerobic plus resistance training was more effective than aerobic training alone to improve the HOMA-AD, suggesting clinical application on obesity, diabetes, atherosclerosis and metabolic syndrome control in the pediatric population.

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