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Rivista di Medicina, Traumatologia e Psicologia dello Sport

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The Journal of Sports Medicine and Physical Fitness 2016 May 11

lingua: Inglese

Research progress on reconstruction of meniscus in tissue engineering

Yu ZHANG 1, 2, Pengsong LI 2, Hai WANG 1, Yiwei WANG 3, Kedong SONG 1, Tianqing LI 1

1 State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian, China; 2 Department of Physical Education, Dalian University of Technology, Dalian, China; 3 Burns Research Group, Anzac Research Institute, University of Sydney, Concord, NSW, Australia


Meniscus damages is most common in sports injuries and aged knees. One third of meniscus lesions are known as white-white zone or nonvascular zones, which are composed of chondrocyte and extracellular matrix composition only. Due to low vascularization the ability of regeneration in such zones is inherently limited, leading to impossible self-regeneration post damage. Meniscus tissue engineering is known for emerging techniques for treating meniscus damage, but there are questions that need to be answered, including an optimal and suitable cell source, the usability of growth factor, the selectivity of optimal biomaterial scaffolds as well as the technology for improving partial reconstruction of meniscus tears. This review focuses on current research on the in vitro re-construction of the meniscus using tissue engineering methods with the expectation to develop a series of tissue engineering meniscus products for the benefit of sports injuries. With rapid growth of clinical demand, the key breakthrough of meniscus tissue engineering research foundation is enlarged to a great extent. This review discusses aspects of meniscus tissue engineering, which is relative to the clinical treatment of meniscus injuries for further support and establishment of fundamental and clinical studies.

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