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Indexed/Abstracted in: Chemical Abstracts, CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,111
Online ISSN 1827-1928
Dinçer S. 1, Altan M. 2, Terzioğlu D. 3, Uslu E. 4, Karşıdağ K. 5, Batu S. 6, Metin G. 1
1 Department of Sports Medicine, Istanbul Medical Faculty, Istanbul University, 34093 Istanbul, Turkey;
2 Department of Physiology, Cerrahpasa Faculty of Medicine, Istanbul University, 34098 Istanbul, Turkey;
3 Department of Biochemistry, Bilecik State Hospital, Bilecik, Turkey;
4 Department of Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey;
5 Department of Endocrinology in Internal Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey;
6 Department of Biochemistry, Faculty of Dentistry, Istanbul University, Istanbul, Turkey
AIM: We aimed to investigate the effects of a regular exercise program on exercise capacity, blood biochemical profiles, certain antioxidant and oxidative stress parameters of type 2 Diabetes Mellitus (DM) patients.
METHODS: Thirty one type 2 DM patients (ages ranging from 42–65 years) who have hemoglobin A1c (HbA1c) levels ≥7.5% and ≤9.5% were included to study and performed two cardiopulmonary exercise tests (CPET) before and after the exercise program. Subjects performed aerobic exercise training for 90 minutes a day; 3 days a week during 12 weeks. Blood samples were collected to analyze certain oxidant and antioxidant parameters [advanced oxidation protein products (AOPP), ferric reducing ability of plasma (FRAP), malondialdehyde (MDA), and sialic acid (SA)], blood lipid profile, fasting blood glucose (FBG) and HbA1c.
RESULTS: At the end of the program HbA1c and FBG, triglyceride (TG) and very-low-density lipoprotein (VLDL) levels decreased and high-density lipoprotein (HDL) increased significantly (p=0.000, p=0.001, p=0.008, p=0,001 and p=0.02 respectively). AOPP, FRAP, SA levels of the patients increased significantly following first CPET (p=0.000, p=0.049, p=0.014 respectively). At the end of the exercise program AOPP level increased significantly following last CPET. Baseline SA level increased significantly following exercise program (p=0.002).
CONCLUSION: We suggest that poor glycemic control which plays the major role in the pathogenesis of DM and its complications would be improved by 12 weeks of a regular exercise program. Whereas the acute exercise induces protein oxidation, regularly aerobic training may enhance the antioxidant status of type 2 DM patients.