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Indexed/Abstracted in: Chemical Abstracts, CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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EPIDEMIOLOGY AND CLINICAL MEDICINE
Şensu DINÇER 1, Mehmet ALTAN 2, Duygu TERZIOĞLU 3, Ezel USLU 4, Kubilay KARŞIDAĞ 5, Şule BATU 6, Gökhan METIN 1
1 Department of Sports Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey; 2 Department of Physiology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey; 3 Department of Biochemistry, Bilecik State Hospital, Bilecik, Turkey; 4 Department of Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey; 5 Department of Endocrinology in Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey; 6 Department of Biochemistry, Faculty of Dentistry, Istanbul University, Istanbul, Turkey
BACKGROUND: We aimed to investigate the effects of a regular exercise program on exercise capacity, blood biochemical profiles, certain antioxidant and oxidative stress parameters of type 2 Diabetes mellitus (DM) patients.
METHODS: Thirty one type 2 DM patients (ages ranging from 42-65 years) who have hemoglobin A1c (HbA1c) levels ≥7.5% and ≤9.5% were included to study and performed two cardiopulmonary exercise tests (CPET) before and after the exercise program. Subjects performed aerobic exercise training for 90 minutes a day; 3 days a week during 12 weeks. Blood samples were collected to analyze certain oxidant and antioxidant parameters (advanced oxidation protein products [AOPP], ferric reducing ability of plasma [FRAP], malondialdehyde [MDA], and sialic acid [SA]), blood lipid profile, fasting blood glucose (FBG) and HbA1c.
RESULTS: At the end of the program HbA1c and FBG, triglyceride (TG) and very-low-density lipoprotein (VLDL) levels decreased and high-density lipoprotein (HDL) increased significantly (P=0.000, P=0.001, P=0.008, P=0,001 and P=0.02, respectively). AOPP, FRAP, SA levels of the patients increased significantly following first CPET (P=0.000, P=0.049, P=0.014 respectively). At the end of the exercise program AOPP level increased significantly following last CPET. Baseline SA level increased significantly following exercise program (P=0.002).
CONCLUSIONS: We suggest that poor glycemic control which plays the major role in the pathogenesis of DM and its complications would be improved by 12 weeks of a regular exercise program. Whereas the acute exercise induces protein oxidation, regularly aerobic training may enhance the antioxidant status of type 2 DM patients.