Home > Riviste > The Journal of Sports Medicine and Physical Fitness > Fascicoli precedenti > The Journal of Sports Medicine and Physical Fitness 2015 April;55(4) > The Journal of Sports Medicine and Physical Fitness 2015 April;55(4):345-51

ULTIMO FASCICOLO
 

ARTICLE TOOLS

Estratti

THE JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS

Rivista di Medicina, Traumatologia e Psicologia dello Sport


Indexed/Abstracted in: Chemical Abstracts, CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,111


eTOC

 

ORIGINAL ARTICLES  EPIDEMIOLOGY AND CLINICAL MEDICINE


The Journal of Sports Medicine and Physical Fitness 2015 April;55(4):345-51

lingua: Inglese

Modulation of TNF-α, TNF-α receptors and IL-6 after treatment with AM3 in professional cyclists

Córdova A. 1, Sureda A. 2, 3, Pons A. 2, 3, Alvarez-Mon M. 4

1 Department of Biochemistry and Physiology, School of Physical Therapy, University of Valladolid, Campus of Soria E-42004, Soria, Spain;
2 Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands, Palma de Mallorca, Spain;
3 CIBER: CB12/03/30038, Fisiopatología de la Obesidad y la Nutrición, CIBERobn, Instituto de Salud Carlos III (ISCIII), Spain;
4 Department of Medicine, Alcalá University, Carretera Madrid-Barcelona, Alcalá de Henares Madrid, Spain


PDF  


AIM: Changes in IL-6, TNF-α, and TNF-α receptors - sTNFRI and sTNFRII - were evaluated in a group of professional cyclists treated with immunomodulator AM3 (Inmunoferón®) for 6 months of training and competition.
METHODS: Sixteen male professional cyclists with a similar training program participated in the study which was designed as a randomized, placebo-controlled, double-blind clinical trial. Venous blood samples were collected in basal conditions, before beginning the supplementation program, and after 90 and 180 days of training and competition season.
RESULTS: No significant differences in biochemical parameters or in IL-6 were evidenced between placebo and AM3-treated groups throughout the study. Plasma TNF-α levels significantly decreased (P<0.05) after 90 days of training in the AM3 treated group. TNF-α receptors increased during training season in both placebo and AM3 treated groups, although the increase was significantly higher (P<0.05) in the AM3 group with respect to the placebo group.
CONCLUSION: The changes produced by regular training and competition were modified throughout the season by AM3 treatment which could reduce the inflammatory response to excessive exercise.

inizio pagina

Publication History

Per citare questo articolo

Corresponding author e-mail

a.cordova@bio.uva.es