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ULTIMO FASCICOLOTHE JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS

Rivista di Medicina, Traumatologia e Psicologia dello Sport

Indexed/Abstracted in: Chemical Abstracts, CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,111

Periodicità: Mensile

ISSN 0022-4707

Online ISSN 1827-1928

 

The Journal of Sports Medicine and Physical Fitness 2013 Febbraio;53(1):93-100

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 ORIGINAL ARTICLES

Effects of heat preconditioning on overload training induced myocardial injury

Yang Y. 1, Li Z. 2, Liu H. 1, Shi W. 3, Zhang J. 3

1 College of Health Science, Wuhan Institute of Physical Education, Wuhan, China;
2 Renmin Hospital, Wuhan University, Wuhan, China;
3 Graduate Department, Wuhan Institute of Physical Education, Wuhan, China

Aim: The present study was to investigate the protective effects and mechanisms of heat preconditioning (HP) on myocardial injury induced by the overload training.
Methods: A total of 25 male Sprague-Dauley (SD) rats were randomly divided into three groups: control group, training group and HP group. The activities of creatine kinase (CK), catalase (CAT) and superoxide dismutase (SOD) of myocardium, apoptosis index (AI), expressions of Bcl-2, Bax, caspase-3, caspase-9, ICAM-1, VCAM-1, and PECAM-1 were determined after 8-week overload training.
Results: Results showed the CK activity, myocardial apoptosis rate and AI in training group were significantly higher than control group and HP group (P<0.05), while the activities of CAT and SOD of training group and HP group were slightly lower than control group (P>0.05). The Bcl-2 expression in HP group was significantly higher than control group and training group, while the ratio of Bcl-2/Bax of training group was significantly lower than control group and HP group. The expressions of caspase-3, caspase-9, ICAM-1, VCAM-1 and PECAM-1 in training group and HP group were significantly higher than control group. Significant differences in the expressions of caspase-3, and caspase-9 was also noted between training group and HP group, but there was no marked difference in the expressions of ICAM-1, VCAM-1 and PECAM-1 between these two groups.
Conclusion: HP could adjust the activities of CK, CAT and SOD, regulate the expressions of apoptosis-related genes and adhesion molecules resulting in enhanced capacity against overload training induced injury and reduced damage to the myocardium.

lingua: Inglese


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