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THE JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
Rivista di Medicina, Traumatologia e Psicologia dello Sport
Indexed/Abstracted in: Chemical Abstracts, CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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The Journal of Sports Medicine and Physical Fitness 2012 Ottobre;52(5):563-8
Cytokines and cellular inflammatory sequence in non-athletes after prolonged exercise
Ostapiuk-Karolczuk J. 1, Zembron-Lacny A. 1, Naczk M. 2, Gajewski M. 3, Kasperska A. 1, Dziewiecka H. 1, Szyszka K. 1 ✉
1 Department of Sport Medicine and Biochemistry, Faculty of Physical Culture Gorzow Wlkp, University of Physical Education, Poznan, Poland;
2 Department of Physiology, Faculty of Physical Culture Gorzow Wlkp, University of Physical Education, Poznan, Poland;
3 Department of Infectious Diseases, Medical University of Gdansk, Gdansk, Poland
AIM: The goal of the study was to clarify the sequence of cytokines and inflammatory cells in non-athletes performed an intense running exercise.
METHODS: Sixteen young healthy men participated in the exercise trial that involved 90-min run at 65% VO2max.
RESULTS: The plasma concentrations of anti-inflammatory cytokines IL-4, IL-6 and IL-10 increased immediately after exercise simultaneously with number of white blood cells. Between IL-6 and IL-10, and neutrophils the relationships were observed. The correlation value for IL-6 and neutrophils was 0.775 whereas for IL-10 and neutrophils was 0.506. The proinflammatory cytokines IL-1β and TNFα were detected at 6 h after exercise and moderately correlated with monocytes count. The high level of proinflammatory cytokines, monocytes and creatine kinase (CK) remained until 48 h rest. The CK activity significantly correlated with IL-1β (r=0.578) and TNFα (r=0.452), and also with monocytes count (r=0.439).
CONCLUSION: The results have shown that: 1) exercise induces anti-inflammatory cytokines production first and then proinflammatory cytokines; and 2) prolonged proinflammatory response is closely related with muscle damage present.