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THE JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
Rivista di Medicina, Traumatologia e Psicologia dello Sport
Indexed/Abstracted in: Chemical Abstracts, CINAHL, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,111
Original articles OTHER AREAS (Biochemistry, Immunology, Kinanthropometry, Neurology, Neurophysiology, Ophtalmology, Pharmacology, Phlebology, ecc.)
The Journal of Sports Medicine and Physical Fitness 2006 Settembre;46(3):509-13
The angiotensin converting enzyme I/D polymorphism in long distance runners
Hruskovicová H. 1, Dzurenková D. 2, Selingerová M. 3, BohuSˇ B. 4, TimkaniCˇová B. 4, Kovács L. 5
1 Division of Medical Genetics Department of Obstetrics and Gynaecology Medical Centre Ljubljana, Slovenia
2 Department of Physical Education Medicine University Hospital Comenius University, Bratislava, Slovak Republic
3 Institute of Sport Sciences Faculty of Physical Education and Sports Comenius University, Bratislava, Slovak Republic
4 Department of Physical Education Medicine Institute of Physiology of Medical Faculty University of P. J. Safárik, Kosice, Slovak Republic
5 Molecular-Genetic Laboratory, University Hospital Comenius University, Bratislava, Slovak Republic
Aim. There is an assumption that ACE I/D polymorphism represents one of the possible genetic factors that might be associated with sports excellence. Recent studies have identified an increased frequency of I allele in elite endurance athletes, long distance runners, rowers and mountaineers. The aim of this study was to test the hypothesis that the ACE I/D polymorphism is associated with enhanced endurance performance.
Methods. We examined this hypothesis by determining ACE I/D allele frequency in 215 marathon runners, 222 half-marathon runners and 18 inline skaters classified by performance (marathon competition results). ACE genotype and allele frequencies were compared with 252 healthy controls.
Results. ACE genotype frequency in the whole cohort did not differ from that in the sedentary controls (P<0.56). However, there was an increase of the I/I genotype incidence amongst successful marathon runners scoring on places from 1st to 150th (P<0.01). These findings were confirmed in the group of inline skaters, similarly demonstrating an increase of the I/I genotype (P<0.01). There was no association found between half marathon runners and the ACE genotype (P<0.59).
Conclusions. An excess of the I allele in long distance runners confirms the association between the ACE I/D polymorphism and endurance sports performance.